NEPHROLITHIASIS.

Cystine nephrolithiasis

Our understanding of the molecular basis of cystinuria has deepened as the result of the causative genes, SLC3A1 and SLC7A9, being identified. The proteins coded for by these genes form a heterodimer responsible for reabsorption of filtered cystine in the proximal tubule. Failure of this transport system to be targeted to the apical membrane, as in the case of SLC3A1 mutations, or failure of th...

Nephrolithiasis: introduction.

Topiramate-induced nephrolithiasis

Nephrolithiasis is a less common side effect of the antiepileptic drug topiramate. We report the case of a 3-year-old boy who presented to the emergency department with abdominal pain; examinations revealed a large calcification in the left kidney. Regular ultrasound examinations are recommended in children using topiramate.

Pathomechanisms of nephrolithiasis.

Lithiasis continues to be an important factor in chronic renal disease, since it leads to chronic tubulo-interstitial nephritis, which is estimated to be involved in 15- 30% of cases of end stage chronic renal insufficiency. It is believed that in order for a stone to be formed, a solid phase needs to be first produced from microcrystals (the nucleus), which are formed from salts (and other sub...

Symptomatic nephrolithiasis complicating pregnancy.

OBJECTIVE To review our experiences with diagnosis and management of symptomatic nephrolithiasis complicating pregnancy and to ascertain the efficacy of renal sonography for initial diagnosis compared with plain x-rays or single-shot intravenous pyelography. METHODS Perinatal outcomes were evaluated for all pregnant women admitted to Parkland Hospital for nephrolithiasis from 1986 to 1999. Di...